CBD can activate, antagonize, or inhibit specific receptors depending on its concentration. These receptors include endocannabinoid (CB1 and CB2), ionotropic (TRP and 5-HT1A), and nuclear (PPARg) receptors.
In one study, people with ALS who received THC and CBD reported reduced spasticity (muscle tightness and stiffness) compared to those who only received THC. The combination is known as the entourage effect.
Anti-Inflammatory Effects
CBD has been shown to have anti-inflammatory properties and reduce the occurrence of inflammatory conditions like arthritis. This is because it interacts with the body’s endocannabinoid system (ECS), a network of receptors, enzymes, and other molecules that help regulate various physiological functions, including inflammation responses.
CBD interacts with the ECS by binding to CB2 receptors, mainly in immune tissues and peripheral organs. By acting on these receptors, CBD helps modulate inflammatory responses by inhibiting the production of pro-inflammatory cytokines and directly suppressing the activation of immune cells, thus reducing their inflammatory activity.
Additionally, CBD has been found to increase the levels of antioxidant enzymes in the skin significantly. These include glutathione peroxidase, thioredoxin reductase, and superoxide dismutase, which are essential in preserving cellular redox balance and protecting against oxidative damage.
CBD has also been shown to decrease chronic neuropathic pain significantly. This is because it blocks pain signals from the brain by acting on the endocannabinoid system. In addition, CBD can significantly reduce the inflammation and swelling associated with this condition by blocking inflammatory markers such as tumor necrosis factor (TNF).
Additionally, CBD has been shown to improve sleep quality in patients with neuropathic pain, helping them to achieve restful and uninterrupted sleep. This is a significant finding since sleep problems are often associated with neuropathic pain.
Sleep Support
CBD may aid with sleep quality by encouraging relaxation, which reduces the stress and anxiety that can lead to insomnia. Additionally, it may be used to treat circadian rhythm abnormalities, which might be brought on by shift employment or other circumstances.
For those who have difficulty falling asleep or staying asleep, it is recommended that you try a high CBD formula such as this blueberry-flavored tincture, which contains 50 mg of hemp-derived CBD and a small amount of THC—not enough to produce the psychoactive effect known as the “high” but enough to deliver the entourage effects and support your healthy sleep cycle.
This sleep aid is also enhanced with chamomile and valerian root extracts, traditionally used to promote relaxation and help ease the mind and body into a calm state that can prepare for a good night’s rest. Its water-soluble nature makes it easy to use and fits into your bedtime wellness routine at home or on the go.
If you’re struggling with sleep problems, talk to a healthcare professional. They can examine and learn more about your lifestyle and sleep habits to determine what could be causing them. They may recommend that you try some tips for better sleep or even a sleep study test to see if they can identify an underlying issue.
Mood Enhancement
There is evidence that CBD might elevate mood and lessen anxiety. Studies suggest it can help alleviate depression, bipolar disorder, and other mood disorders. It also may help treat stress and reduce cravings for drugs like heroin, per preclinical research.
It might extend the life of people with an aggressive form of cancer called glioblastoma, though more research is needed. CBD might also improve cancer-related symptoms, including nausea and pain, but more study is required.
When combined with THC, the main mind-altering ingredient found in cannabis, CBD tempers the high that can sometimes be associated with THC. This creates an “entourage effect” and enhances the therapeutic benefits of both chemicals. According to one study, CBD can reduce drowsiness and make it easier to fall asleep with THC.
CBD can be found in many products, including tinctures, capsules, and vaporized oils. However, it’s essential to choose third-party products tested for purity and quality. Before using any new product, including CBD, it’s also a good idea to consult your doctor. In some cases, CBD can interact with certain medications. This could lead to sedation or abnormal liver function test results. It might also cause drowsiness or diarrhea.
Pain Relief
CBD can alleviate pain by binding to receptors in the brain that are involved in sending signals to the nerves. It is also a great way to reduce inflammation that causes pain. This makes it an ideal treatment for various ailments, including chronic back pain and arthritis.
For those experiencing pain due to an injury or illness, it contains CBD extract in addition to white willow bark and menthol. It can be applied to the skin or ingested as a capsule. This product is made with all-natural ingredients and formulated by an expert botanist.
Another source of pain is neuropathy, which is caused when the nerves send incorrect messages due to damage or disease. A 2022 study found that topical CBD oil effectively reduced neuropathic pain in multiple sclerosis patients. Neuropathic pain is characterized by sharp, burning, or itching sensations and can be hard to control.
Researchers are investigating the potential of CBD for anxiety, sleep, and substance misuse disorder, as well as extending life in people with a deadly form of cancer called glioblastoma. However, more research is needed to support these findings and help physicians understand the best dosing and usage.
For now, it is best to stick to high-quality, full-spectrum products that have been batch-tested by an independent laboratory to verify tetrahydrocannabinol levels and no pesticides or heavy metals.
